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Article

Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.

Science (New York, N.Y.) - 13 Nov 1992

Peliska J A, Benkovic S J

Abstract excerpt

Two DNA strand transfer reactions occur during retroviral reverse transcription. The mechanism of the first, minus strand strong-stop DNA, transfer has been studied in vitro with human immunodeficiency virus 1 reverse transcriptase (HIV-1 RT) and a model template-primer system derived from the HIV-1 genome. The results reveal that HIV-1 RT alone can catalyze DNA strand transfer reactions. Two kinetically distinct...

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Identifiers

PMID: 1279806
DOI: 10.1126/science.1279806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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