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Article

Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.

Science (New York, N.Y.) - 13 Nov 1992

Peliska J A, Benkovic S J

Abstract excerpt

Two DNA strand transfer reactions occur during retroviral reverse transcription. The mechanism of the first, minus strand strong-stop DNA, transfer has been studied in vitro with human immunodeficiency virus 1 reverse transcriptase (HIV-1 RT) and a model template-primer system derived from the HI...

Topics

Base Sequence
Catalysis
DNA, Viral
Deoxyribonucleotides
HIV Reverse Transcriptase
HIV-1
Kinetics
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization
RNA, Transfer
RNA, Viral
RNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ribonuclease H

Templates, Genetic

Source

Identifiers

PMID: 1279806
DOI: 10.1126/science.1279806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1279806-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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