Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.

doi:10.1093/nar/gkr694

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.

Nucleic acids research - 1 Jan 2012

Ndongwe Tanyaradzwa P, Adedeji Adeyemi O, Michailidis Eleftherios, Ong Yee Tsuey, Hachiya Atsuko, Marchand Bruno, Ryan Emily M, Rai Devendra K, Kirby Karen A, Whatley Angela S, Burke Donald H, Johnson Marc, Ding Shilei, Zheng Yi-Min, Liu Shan-Lu, Kodama Ei-Ichi, Delviks-Frankenberry Krista A, Pathak Vinay K, Mitsuya Hiroaki, Parniak Michael A, Singh Kamalendra, Sarafianos Stefan G

Abstract excerpt

We report key mechanistic differences between the reverse transcriptases (RT) of human immunodeficiency virus type-1 (HIV-1) and of xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus that can infect human cells. Steady and pre-steady state kinetics demonstrated that XMRV RT is significantly less efficient in DNA synthesis and in unblocking chain-terminated primers. Surface plasmon resonance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aptamers, Nucleotide

Share to HIV Reverse Transcriptase

Share to Moloney murine leukemia virus

Share to Organophosphonates

Share to RNA-Directed DNA Polymerase

Share to Tenofovir

Share to Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 21908397
DOI: 10.1093/nar/gkr694
PMCID: PMC3245923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.PMID 21908397Read ↗

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.Semantic proximity Read ↗

Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.Semantic proximity Read ↗

Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptases.Semantic proximity Read ↗

Physiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.Semantic proximity Read ↗

Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency.Semantic proximity Read ↗

A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions.Semantic proximity Read ↗

Human Immunodeficiency Virus Reverse Transcriptase: 25 Years of Research, Drug Discovery, and PromiseSemantic proximity Read ↗

Virologic and enzymatic studies revealing the mechanism of K65R- and Q151M-associated HIV-1 drug resistance towards emtricitabine and lamivudine.Semantic proximity Read ↗

Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.Semantic proximity Read ↗

Differential Influence of Nucleoside Analog-resistance Mutations K65R and L74V on the Overall Mutation Rate and Error Specificity of Human Immunodeficiency Virus Type 1 Reverse TranscriptaseSemantic proximity Read ↗

Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3GSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.