Article
A new and efficient DNA enzyme for the sequence-specific cleavage of RNA.
Journal of molecular biology - 19 Oct 2001
Feldman A R, Sen D
Abstract excerpt
A new DNA enzyme, the "Bipartite DNAzyme", suitable for the sequence-specific cleavage of RNA, was obtained from a random DNA library by in vitro selection. Only a single family of catalytic molecules emerged from the selection, and a 22 nucleotide consensus sequence common to all clones defined a putative catalytic core. The most abundant clone self-cleaved at a single internal ribonucleotide phosphodiester with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.