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Article

HIV-1 proviral DNA excision using an evolved recombinase.

Science (New York, N.Y.) - 29 Jun 2007

Sarkar Indrani, Hauber Ilona, Hauber Joachim, Buchholz Frank

Abstract excerpt

HIV-1 integrates into the host chromosome and persists as a provirus flanked by long terminal repeats (LTRs). To date, treatment regimens primarily target the virus enzymes or virus-cell fusion, but not the integrated provirus. We report here the substrate-linked protein evolution of a tailored recombinase that recognizes an asymmetric sequence within an HIV-1 LTR. This evolved recombinase efficiently excised...

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Identifiers

PMID: 17600219
DOI: 10.1126/science.1141453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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