Article
DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge.
Intervirology - 1 Jan 2000
Isaguliants M G, Petrakova N N, Zuber B, Pokrovskaya K, Gizatullin R, Kostyuk D A, Kjerrström A, Winberg G, Kochetkov S N, Hinkula J, Wahren B
Abstract excerpt
The present study was undertaken to examine the immunogenicity of a single plasmid DNA representing the reverse transcriptase (RT) of HIV-1. Plasmids containing the enzymatically active RT as well as a mutated nonenzymatically active RT with nucleotide (nt)-binding motifs of YMDD and YMLL, respectively, were used to immunize mice. Both constructs induced similar good antibody and T cell responses, with a tendency...
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