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Article

Mechanism and fidelity of HIV reverse transcriptase.

1 Dec 1992

Abstract excerpt

We have examined the RNA-dependent and DNA-dependent polymerase and ribonuclease H catalytic activities of human immunodeficiency virus reverse transcriptase using rapid transient kinetic methods with defined synthetic 25/45-mer DNA/RNA and DNA/DNA primer/templates. The Kd value for interaction of the enzyme with duplex DNA was 4.7 nM, and the value for RNA/DNA heteroduplex was of similar magnitude. A pre-steady...

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PMID: 1281479
DOI: 10.1016/s0021-9258(18)35706-5

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