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Article

RNA cleaving '10-23' DNAzymes with enhanced stability and activity.

Nucleic acids research - 15 Oct 2003

Schubert Steffen, Gül Deniz C, Grunert Hans-Peter, Zeichhardt Heinz, Erdmann Volker A, Kurreck Jens

Abstract excerpt

'10-23' DNAzymes can be used to cleave any target RNA in a sequence-specific manner. For applications in vivo, they have to be stabilised against nucleolytic attack by the introduction of modified nucleotides without obstructing cleavage activity. In this study, we optimise the design of a DNAzym...

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Identifiers

PMID: 14530446
DOI: 10.1093/nar/gkg791
PMCID: PMC219472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14530446-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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