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Article

Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy.

Antiviral research - 1 Feb 2016

De Silva Feelixge Harshana S, Stone Daniel, Pietz Harlan L, Roychoudhury Pavitra, Greninger Alex L, Schiffer Joshua T, Aubert Martine, Jerome Keith R

Abstract excerpt

Incurable chronic viral infections are a major cause of morbidity and mortality worldwide. One potential approach to cure persistent viral infections is via the use of targeted endonucleases. Nevertheless, a potential concern for endonuclease-based antiviral therapies is the emergence of treatment resistance. Here we detect for the first time an endonuclease-resistant infectious virus that is found with high...

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Share to Endonucleases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26718067
DOI: 10.1016/j.antiviral.2015.12.007
PMCID: PMC4724322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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