Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype.

doi:10.1002/jbmr.243

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Article

Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2011

Fonseca Tatiana L, Jorgetti Vanda, Costa Cristiane C, Capelo Luciane P, Covarrubias Ambart E, Moulatlet Ana C, Teixeira Marilia B, Hesse Eric, Morethson Priscilla, Beber Eduardo H, Freitas Fatima R, Wang Charles C, Nonaka Keico O, Oliveira Ricardo, Casarini Dulce E, Zorn Telma M, Brum Patricia C, Gouveia Cecilia H

Abstract excerpt

Evidence demonstrates that sympathetic nervous system (SNS) activation causes osteopenia via β(2)-adrenoceptor (β2-AR) signaling. Here we show that female mice with chronic sympathetic hyperactivity owing to double knockout of adrenoceptors that negatively regulate norepinephrine release, α(2A)-AR and α(2C)-AR (α(2A) /α(2C)-ARKO), present an unexpected and generalized phenotype of high bone mass with decreased...

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PMID: 20814988
DOI: 10.1002/jbmr.243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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