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Article

The molecular clock mediates leptin-regulated bone formation.

Cell - 9 Sept 2005

Fu Loning, Patel Millan S, Bradley Allan, Wagner Erwin F, Karsenty Gerard

Abstract excerpt

The hormone leptin is a regulator of bone remodeling, a homeostatic function maintaining bone mass constant. Mice lacking molecular-clock components (Per and Cry), or lacking Per genes in osteoblasts, display high bone mass, suggesting that bone remodeling may also be subject to circadian regulation. Moreover, Per-deficient mice experience a paradoxical increase in bone mass following leptin...

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Identifiers

PMID: 16143109
DOI: 10.1016/j.cell.2005.06.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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