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Article

Deletion of β-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2012

Pierroz Dominique D, Bonnet Nicolas, Bianchi Estelle N, Bouxsein Mary L, Baldock Paul A, Rizzoli René, Ferrari Serge L

Abstract excerpt

As they age, mice deficient for the β2-adrenergic receptor (Adrb2(-/-) ) maintain greater trabecular bone microarchitecture, as a result of lower bone resorption and increased bone formation. The role of β1-adrenergic receptor signaling and its interaction with β2-adrenergic receptor on bone mass regulation, however, remains poorly understood. We first investigated the skeletal response to mechanical stimulation...

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Identifiers

PMID: 22407956
DOI: 10.1002/jbmr.1594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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