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Article

Bone phenotypes of P2 receptor knockout mice.

Frontiers in bioscience (Scholar edition) - 1 Jun 2011

Orriss Isabel, Syberg Susanne, Wang Ning, Robaye Bernard, Gartland Alison, Jorgensen Niklas, Arnett Tim, Boeynaems Jean-Marie

Abstract excerpt

The action of extracellular nucleotides is mediated by ionotropic P2X receptors and G-protein coupled P2Y receptors. The human genome contains 7 P2X and 8 P2Y receptor genes. Knockout mice strains are available for most of them. As their phenotypic analysis is progressing, bone abnormalities have been observed in an impressive number of these mice: distinct abnormalities in P2X7-/- mice, depending on the gene...

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Identifiers

PMID: 21622253
DOI: 10.2741/208

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