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Article

Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual

28 Mar 2011

Abstract excerpt

The sympathetic nervous system, whose activity is regulated by leptin signaling in the brain, is a major regulator of bone mass accrual. To determine the identity of the cell type in which the sympathetic tone signals to inhibit bone mass accrual, we performed a systematic, cell-specific analysis of the function of the β2 adrenergic receptor (Adrβ2) and various genes implicated in the pathway in the mouse. This...

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PMID: 21444660
DOI: 10.1084/jem.20102608

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