Article
Lack of α2C-Adrenoceptor Results in Contrasting Phenotypes of Long Bones and Vertebra and Prevents the Thyrotoxicosis-Induced Osteopenia.
PloS one - 1 Jan 2016
Cruz Grecco Teixeira Marilia Bianca, Martins Gisele Miyamura, Miranda-Rodrigues Manuela, De Araújo Iasmin Ferreira, Oliveira Ricardo, Brum Patrícia Chakur, Azevedo Gouveia Cecilia Helena
Abstract excerpt
A series of studies have demonstrated that activation of the sympathetic nervous system (SNS) causes osteopenia via β2-adrenoceptor (β2-AR) signaling. However, in a recent study, we found an unexpected and generalized phenotype of high bone mass in female mice with chronic sympathetic hyperactivity, due to double gene inactivation of adrenoceptors that negatively regulate norepinephrine release, α2A-and α2C-AR...
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