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Article

ADRA2A is involved in neuro-endocrine regulation of bone resorption.

Journal of cellular and molecular medicine - 1 Jul 2015

Mlakar Vid, Jurkovic Mlakar Simona, Zupan Janja, Komadina Radko, Prezelj Janez, Marc Janja

Abstract excerpt

Adrenergic stimulation is important for osteoclast differentiation and bone resorption. Previous research shows that this happens through β2-adrenergic receptor (AR), but there are conflicting evidence on presence and role of α2A-AR in bone. The aim of this study was to investigate the presence of α2A-AR and its involvement in neuro-endocrine signalling of bone remodelling in humans. Real-time polymerase chain...

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Bone Remodeling
Bone Resorption
Enzyme Assays
Luciferases
Neurosecretory Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Adrenergic, alpha-2

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PMID: 25818344
DOI: 10.1111/jcmm.12505
PMCID: PMC4511350

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