Article

Estrogen Signaling in Arcuate <i>Kiss1</i> Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice

2018-05-05

Abstract excerpt

Central estrogen signaling coordinates energy expenditure, reproduction, and in concert with peripheral estrogen impacts skeletal homeostasis in female rodents. Here, we ablate estrogen receptor alpha (ERα) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results in exceptionally strong trabecular and cortical bones, whose density surpasses other reported mouse models. Ste...

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Literature Corpus work: 4976eb8d-d6dd-5dfd-92b3-168424a3bf0d
DOI: 10.1101/315283

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