Article
Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice.
Bone - 1 Dec 2017
Le Phuong T, Bishop Kathleen A, Maridas David E, Motyl Katherine J, Brooks Daniel J, Nagano Kenichi, Baron Roland, Bouxsein Mary L, Rosen Clifford J
Abstract excerpt
Misty mice (m/m) have a loss of function mutation in Dock7 gene, a guanine nucleotide exchange factor, resulting in low bone mineral density, uncoupled bone remodeling and reduced bone formation. Dock7 has been identified as a modulator of osteoblast number and in vitro osteogenic differentiation in calvarial osteoblast culture. In addition, m/m exhibit reduced preformed brown adipose tissue innervation and...
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