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Article

Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice.

Molecular and cellular biology - 1 Aug 2003

Sainsbury Amanda, Baldock Paul A, Schwarzer Christoph, Ueno Naohiko, Enriquez Ronaldo F, Couzens Michelle, Inui Akio, Herzog Herbert, Gardiner Edith M

Abstract excerpt

Neuropeptide Y regulates numerous physiological processes via at least five different Y receptors, but the specific roles of each receptor are still unclear. We previously demonstrated that Y2 receptor knockout results in a lean phenotype, increased cancellous bone volume, and an increase in plasma pancreatic polypeptide (PP), a ligand for Y4 receptors. PP-overexpressing mice are also known to have a lean...

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Identifiers

PMID: 12861009
DOI: 10.1128/MCB.23.15.5225-5233.2003
PMCID: PMC165708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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