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Article

β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis.

Frontiers in immunology - 1 Jan 2021

Rösch Gundula, Muschter Dominique, Taheri Shahed, El Bagdadi Karima, Dorn Christoph, Meurer Andrea, Zaucke Frank, Schilling Arndt F, Grässel Susanne, Straub Rainer H, Jenei-Lanzl Zsuzsa

Abstract excerpt

Purpose: Recent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression. However, the importance of β2-AR has not yet been investigated in knee OA. Therefore, we examined the development of knee OA in β2-AR-deficient (Adrb2-/- ) mice after surgical OA...

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Share to Bone Remodeling
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Osteoarthritis, Knee

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Share to Receptors, Adrenergic, beta-2

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Source

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Identifiers

PMID: 35095883
DOI: 10.3389/fimmu.2021.801505
PMCID: PMC8794706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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