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Article

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.

PLoS pathogens - 19 Aug 2010

Ylinen Laura M J, Price Amanda J, Rasaiyaah Jane, Hué Stéphane, Rose Nicola J, Marzetta Flavia, James Leo C, Towers Greg J

Abstract excerpt

TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5alpha but they have distinct lentiviral specificities, conferring HIV-1 restriction in New World owl monkeys and HIV-2 restriction in Old World rhesus macaques. Here we provide evidence that Asian macaque TRIMCyps have acquired...

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Identifiers

PMID: 20808866
DOI: 10.1371/journal.ppat.1001062
PMCID: PMC2924388

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Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.PMID 20808866Read ↗

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