Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Independent evolution of an antiviral TRIMCyp in rhesus macaques

19 Feb 2008

Abstract excerpt

The antiretroviral restriction factor TRIM5 has recently emerged as an important mediator of innate immunity and species-specific inhibition of retroviral replication in mammals. Selection pressure from pathogenic infection has driven rapid evolution of TRIM5 genes, leading to the antiviral specificities we see today. Remarkably, the New World owl monkey (Aotus trivirgatus) encodes a TRIM5 protein in which the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV Research and Treatment
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18287035
DOI: 10.1073/pnas.0709003105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Independent evolution of an antiviral TRIMCyp in rhesus macaquesPMID 18287035Read ↗

Evolution of a TRIM5-CypA splice isoform in old world monkeys.Semantic proximity Read ↗

Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1.Semantic proximity Read ↗

Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate speciesSemantic proximity Read ↗

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.Semantic proximity Read ↗

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.Semantic proximity Read ↗

Evolution of the antiretroviral restriction factor TRIMCyp in Old World primates.Semantic proximity Read ↗

TRIMCyp expression in Old World primates <i>Macaca nemestrina</i> and <i>Macaca fascicularis</i>Semantic proximity Read ↗

TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque, negatively modulates TRIM5α activity.Semantic proximity Read ↗

Diversity of TRIM5α and TRIMCyp sequences in cynomolgus macaques from different geographical origins.Semantic proximity Read ↗

Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis.Semantic proximity Read ↗

TRIM5α and Species Tropism of HIV/SIVSemantic proximity Read ↗

Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.