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Article

Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis).

The Journal of general virology - 1 Mar 2012

Saito Akatsuki, Kono Ken, Nomaguchi Masako, Yasutomi Yasuhiro, Adachi Akio, Shioda Tatsuo, Akari Hirofumi, Nakayama Emi E

Abstract excerpt

The antiretroviral factor tripartite motif protein 5 (TRIM5) gene-derived isoform (TRIMCyp) has been found in at least three species of Old World monkey: rhesus (Macaca mulatta), pig-tailed (Macaca nemestrina) and cynomolgus (Macaca fascicularis) macaques. Although the frequency of TRIMCyp has been well studied in rhesus and pig-tailed macaques, the frequency and prevalence of TRIMCyp in cynomolgus macaques...

Topics

Animals
Cyclophilin A
Genetic Variation
HIV-1
HIV-2
Haplotypes
Indonesia
Macaca fascicularis
Malaysia
Molecular Sequence Data
Philippines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phylogeography

Protein Isoforms

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 22113010
DOI: 10.1099/vir.0.038075-0
PMCID: PMC3352356

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis).PMID 22113010Read ↗

[TRIMCyp frequency of the cynomolgus macaque (Macaca fascicularis) in captivity in China].Semantic proximity Read ↗

The TRIMCyp genotype in four species of macaques in China.Semantic proximity Read ↗

Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis.Semantic proximity Read ↗

Diversity of TRIM5α and TRIMCyp sequences in cynomolgus macaques from different geographical origins.Semantic proximity Read ↗

Evolution of the antiretroviral restriction factor TRIMCyp in Old World primates.Semantic proximity Read ↗

TRIM5 allelic polymorphism in macaque species/populations of different geographic origins: its impact on SIV vaccine studies.Semantic proximity Read ↗

TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1.Semantic proximity Read ↗

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.Semantic proximity Read ↗

Genotyping of TRIM5 locus in northern pig-tailed macaques (Macaca leonina), a primate species susceptible to Human Immunodeficiency Virus type 1 infection.Semantic proximity Read ↗

Independent evolution of an antiviral TRIMCyp in rhesus macaquesSemantic proximity Read ↗

TRIM5α and Species Tropism of HIV/SIVSemantic proximity Read ↗

Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities.Semantic proximity Read ↗

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