Article
Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5α specificity.
PLoS pathogens - 1 May 2013
McCarthy Kevin R, Schmidt Aaron G, Kirmaier Andrea, Wyand Allison L, Newman Ruchi M, Johnson Welkin E
Abstract excerpt
Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor three functionally distinct Trim5 alleles: Trim5α(Q) , Trim5α(TFP) and Trim5(CypA) . Despite the high degree of amino acid identity between Trim5α(Q) and Trim5α(TFP) alleles, the Q/TFP polymorphism results in the differential restriction of some primate lentiviruses, suggesting these alleles differ in how they engage these...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Biological Evolution
- Capsid
- Cats
- Cell Line
- HIV
- Humans
- Macaca mulatta
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- Protein Structure, Quaternary