Article
Evolution of a TRIM5-CypA splice isoform in old world monkeys.
PLoS pathogens - 29 Feb 2008
Newman Ruchi M, Hall Laura, Kirmaier Andrea, Pozzi Lu-Ann, Pery Erez, Farzan Michael, O'Neil Shawn P, Johnson Welkin
Abstract excerpt
The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif for which the family is named. However, the C-termini of TRIM proteins vary, and include at least nine evolutionarily distinct, unrelated protein domains. Antiviral restriction factor TRIM5alpha has a C-terminal...
Topics
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Cercopithecidae
- Cyclophilin A
- Evolution, Molecular
- Genotype
- HIV Infections
- HIV-1
- Homozygote
- Immunity, Innate