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Article

Diversity of TRIM5α and TRIMCyp sequences in cynomolgus macaques from different geographical origins.

Immunogenetics - 1 Apr 2012

Berry Neil J, Marzetta Flavia, Towers Greg J, Rose Nicola J

Abstract excerpt

The TRIM5α restriction factor can protect some species of monkeys, but not humans, from HIV infection. It has also emerged that some monkeys have a cyclophilin A domain retrotransposed into the TRIM5 locus resulting in the expression of a TRIMCyp protein with anti-retroviral activity. A high degree of sequence variation in the primate TRIM5 gene has been reported that varies between populations of rhesus...

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Source

Identifiers

PMID: 22124667
DOI: 10.1007/s00251-011-0585-x

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Diversity of TRIM5α and TRIMCyp sequences in cynomolgus macaques from different geographical origins.PMID 22124667Read ↗

Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis).Semantic proximity Read ↗

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Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis.Semantic proximity Read ↗

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Evolution of a TRIM5-CypA splice isoform in old world monkeys.Semantic proximity Read ↗

Independent evolution of an antiviral TRIMCyp in rhesus macaquesSemantic proximity Read ↗

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Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities.Semantic proximity Read ↗

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