Article
Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1.
Virology - 1 Aug 2006
Diaz-Griffero Felipe, Vandegraaff Nick, Li Yuan, McGee-Estrada Kathleen, Stremlau Matthew, Welikala Sohanya, Si Zhihai, Engelman Alan, Sodroski Joseph
Abstract excerpt
In owl monkeys, a retrotransposition event replaced the gene encoding the retroviral restriction factor TRIM5alpha with one encoding TRIMCyp, a fusion between the RING, B-box 2 and coiled-coil domains of TRIM5 and cyclophilin A. TRIMCyp restricts human immunodeficiency virus (HIV-1) infection by a mechanism dependent on the interaction of the cyclophilin A moiety and the HIV-1 capsid protein. Here, we show that...
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