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Article

Active site remodeling switches HIV specificity of antiretroviral TRIMCyp.

Nature structural & molecular biology - 1 Oct 2009

Price Amanda J, Marzetta Flavia, Lammers Michael, Ylinen Laura M J, Schaller Torsten, Wilson Sam J, Towers Greg J, James Leo C

Abstract excerpt

TRIMCyps are primate antiretroviral proteins that potently inhibit HIV replication. Here we describe how rhesus macaque TRIMCyp (RhTC) has evolved to target and restrict HIV-2. We show that the ancestral cyclophilin A (CypA) domain of RhTC targets HIV-2 capsid with weak affinity, which is strongly increased in RhTC by two mutations (D66N and R69H) at the expense of HIV-1 binding. These mutations disrupt a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19767750
DOI: 10.1038/nsmb.1667
PMCID: PMC3556581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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