Article
TRIM5 alpha drives SIVsmm evolution in rhesus macaques.
PLoS pathogens - 1 Jan 2013
Wu Fan, Kirmaier Andrea, Goeken Robert, Ourmanov Ilnour, Hall Laura, Morgan Jennifer S, Matsuda Kenta, Buckler-White Alicia, Tomioka Keiko, Plishka Ronald, Whitted Sonya, Johnson Welkin, Hirsch Vanessa M
Abstract excerpt
The antagonistic interaction with host restriction proteins is a major driver of evolutionary change for viruses. We previously reported that polymorphisms of the TRIM5α B30.2/SPRY domain impacted the level of SIVsmm viremia in rhesus macaques. Viremia in macaques homozygous for the non-restrictive TRIM5α allele TRIM5(Q) was significantly higher than in macaques expressing two restrictive TRIM5alpha alleles...
Topics
- Alleles
- Amino Acid Substitution
- Animals
- Base Sequence
- Carrier Proteins
- Evolution, Molecular
- Macaca mulatta
- Molecular Sequence Data
- Mutation, Missense
- Protein Structure, Secondary