Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles.

doi:10.1128/JVI.79.18.11580-11587.2005

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Article

Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles.

Journal of virology - 1 Sept 2005

Ylinen Laura M J, Keckesova Zuzana, Wilson Sam J, Ranasinghe Srinika, Towers Greg J

Abstract excerpt

Primate lentiviruses have narrow host ranges, due in part to their sensitivities to mammalian intracellular antiviral factors such as APOBEC3G and TRIM5alpha. Despite the protection provided by this innate immune system, retroviruses are able to transfer between species where they can cause disease. This is true for sooty mangabey simian immunodeficiency virus, which has transferred to humans as HIV-2 and to...

Topics

Alleles
Amino Acid Sequence
Animals
Antiviral Restriction Factors
Base Sequence
Binding Sites
Carrier Proteins
Cats
Cell Line
Cyclophilin A
DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Viral

HIV-2

Humans

Macaca mulatta

Molecular Sequence Data

Mutation

Proteins

Source

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Identifiers

PMID: 16140735
DOI: 10.1128/JVI.79.18.11580-11587.2005
PMCID: PMC1212619

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