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Article

Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis.

Journal of virology - 1 Oct 2011

Dietrich Elizabeth A, Brennan Greg, Ferguson Betsy, Wiseman Roger W, O'Connor David, Hu Shiu-Lok

Abstract excerpt

The retroviral restriction factor TRIMCyp, derived from the TRIM5 gene, blocks replication at a postentry step. TRIMCyp has so far been found in four species of Asian macaques, Macaca fascicularis, M. mulatta, M. nemestrina, and M. leonina. M. fascicularis is commonly used as a model for AIDS research, but TRIMCyp has not been analyzed in detail in this species. We analyzed the prevalence of TRIMCyp in samples...

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Identifiers

PMID: 21795330
DOI: 10.1128/JVI.00097-11
PMCID: PMC3196437

Genes

TRIM5

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis.PMID 21795330Read ↗

Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis).Semantic proximity Read ↗

[TRIMCyp frequency of the cynomolgus macaque (Macaca fascicularis) in captivity in China].Semantic proximity Read ↗

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The TRIMCyp genotype in four species of macaques in China.Semantic proximity Read ↗

Evolution of the antiretroviral restriction factor TRIMCyp in Old World primates.Semantic proximity Read ↗

Independent evolution of an antiviral TRIMCyp in rhesus macaquesSemantic proximity Read ↗

TRIMCyp expression in Old World primates <i>Macaca nemestrina</i> and <i>Macaca fascicularis</i>Semantic proximity Read ↗

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.Semantic proximity Read ↗

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Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1.Semantic proximity Read ↗

Evolution of a TRIM5-CypA splice isoform in old world monkeys.Semantic proximity Read ↗

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