Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.

doi:10.1001/archneurol.2010.201

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Article

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.

Archives of neurology - 1 Dec 2010

Jun Gyungah, Naj Adam C, Beecham Gary W, Wang Li-San, Buros Jacqueline, Gallins Paul J, Buxbaum Joseph D, Ertekin-Taner Nilufer, Fallin M Daniele, Friedland Robert, Inzelberg Rivka, Kramer Patricia, Rogaeva Ekaterina, St George-Hyslop Peter, Cantwell Laura B, Dombroski Beth A, Saykin Andrew J, Reiman Eric M, Bennett David A, Morris John C, Lunetta Kathryn L, Martin Eden R, Montine Thomas J, Goate Alison M, Blacker Deborah, Tsuang Debby W, Beekly Duane, Cupples L Adrienne, Hakonarson Hakon, Kukull Walter, Foroud Tatiana M, Haines Jonathan, Mayeux Richard, Farrer Lindsay A, Pericak-Vance Margaret A, Schellenberg Gerard D

Abstract excerpt

OBJECTIVES: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes. DESIGN: Association study of AD and CLU, PICALM, CR1, and APOE genotypes. SETTING: Academic research institutions in the United States, Canada, and Israel. PARTICIPANTS: Seven thousand seventy cases with...

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PMID: 20697030
DOI: 10.1001/archneurol.2010.201
PMCID: PMC3048805

Genes

APOE
PICALM
CLU

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Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.PMID 20697030Read ↗

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