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Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.

Neurobiology of aging - 1 Jan 2012

Chen Lu Hua, Kao Patrick Yu Ping, Fan Yan Hui, Ho Deborah Tip Yin, Chan Cherry Sze Yan, Yik Ping Yiu, Ha Joyce Cheuk Tung, Chu Leung Wing, Song You-Qiang

Abstract excerpt

In this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from genome-wide association studies (GWAS) in a southern Chinese population. Eight hundred twelve participants consisting of 462 late-onset Alzheimer's disease (LOAD) patients and 350 nondemented control subjects were recruited. We found by multivariate logistic regression analysis, that...

Topics

Alzheimer Disease
Apolipoprotein E4
Asian People
Case-Control Studies
Clusterin
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Monomeric Clathrin Assembly Proteins

Multivariate Analysis

Polymorphism, Single Nucleotide

Receptors, Complement 3b

Source

Identifiers

PMID: 22015308
DOI: 10.1016/j.neurobiolaging.2011.09.016

Genes

CLU
PICALM
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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