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Article

Association of CLU and PICALM variants with Alzheimer's disease.

Neurobiology of aging - 1 Mar 2012

Kamboh M Ilyas, Minster Ryan L, Demirci F Yesim, Ganguli Mary, Dekosky Steven T, Lopez Oscar L, Barmada M Michael

Abstract excerpt

Two recent large genome-wide association studies have reported significant associations in the CLU (APOJ), CR1, and PICALM genes with the risk of Alzheimer's disease (AD). In order to replicate these findings, we examined 7 single nucleotide polymorphisms (SNPs) most significantly implicated by these studies in a large case-control sample comprising 2707 individuals. Principle components analysis revealed no...

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Aged
Alzheimer Disease
Case-Control Studies
Clusterin
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Monomeric Clathrin Assembly Proteins

Polymorphism, Single Nucleotide

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Identifiers

PMID: 20570404
DOI: 10.1016/j.neurobiolaging.2010.04.015
PMCID: PMC3010357

Genes

CLU
PICALM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Association of CLU and PICALM variants with Alzheimer's disease.PMID 20570404Read ↗

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.Semantic proximity Read ↗

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.Semantic proximity Read ↗

Replication of CLU, CR1, and PICALM associations with alzheimer disease.Semantic proximity Read ↗

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.Semantic proximity Read ↗

Genome-wide analysis of genetic loci associated with Alzheimer disease.Semantic proximity Read ↗

Genetic variability in CLU and its association with Alzheimer's disease.Semantic proximity Read ↗

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.Semantic proximity Read ↗

Implication of common and disease specific variants in CLU, CR1, and PICALM.Semantic proximity Read ↗

Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.Semantic proximity Read ↗

Association of MTHFR and PICALM polymorphisms with Alzheimer's disease.Semantic proximity Read ↗

PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients.Semantic proximity Read ↗

rs3851179 Polymorphism at 5' to the PICALM Gene is Associated with Alzheimer and Parkinson Diseases in Brazilian Population.Semantic proximity Read ↗

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