Article
Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations.
Neurobiology of aging - 1 Apr 2011
Lambert Jean-Charles, Zelenika Diana, Hiltunen Mikko, Chouraki Vincent, Combarros Onofre, Bullido Maria J, Tognoni Gloria, Fiévet Nathalie, Boland Anne, Arosio Beatrice, Coto Eliecer, Del Zompo Maria, Mateo Ignacio, Frank-Garcia Ana, Helisalmi Seppo, Porcellini Elisa, Pilotto Alberto, Forti Paola, Ferri Raffaele, Delepine Marc, Scarpini Elio, Siciliano Gabriele, Solfrizzi Vincenzo, Sorbi Sandro, Spalletta Gianfranco, Ravaglia Giovanni, Valdivieso Fernando, Alvarez Victoria, Bosco Paolo, Mancuso Michelangelo, Panza Francesco, Nacmias Benedetta, Bossù Paola, Piccardi Paola, Annoni Giorgio, Seripa Davide, Galimberti Daniela, Licastro Federico, Lathrop Mark, Soininen Hilkka, Amouyel Philippe
Abstract excerpt
Recent genome-wide association studies have identified 5 loci (BIN1, CLU, CR1, EXOC3L2, and PICALM) as genetic determinants of Alzheimer's disease (AD). We attempted to confirm the association between these genes and the AD risk in 3 contrasting European populations (from Finland, Italy, and Spain). Because CLU and CR1 had already been analyzed in these populations, we restricted our investigation to BIN1,...
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