Article
Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
Human molecular genetics - 15 Aug 2010
Corneveaux Jason J, Myers Amanda J, Allen April N, Pruzin Jeremy J, Ramirez Manuel, Engel Anzhelika, Nalls Michael A, Chen Kewei, Lee Wendy, Chewning Kendria, Villa Stephen E, Meechoovet Hunsar B, Gerber Jill D, Frost Danielle, Benson Hollie L, O'Reilly Sean, Chibnik Lori B, Shulman Joshua M, Singleton Andrew B, Craig David W, Van Keuren-Jensen Kendall R, Dunckley Travis, Bennett David A, De Jager Philip L, Heward Christopher, Hardy John, Reiman Eric M, Huentelman Matthew J
Abstract excerpt
In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single...
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