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Article

CR1 is associated with amyloid plaque burden and age-related cognitive decline.

Annals of neurology - 1 Mar 2011

Chibnik Lori B, Shulman Joshua M, Leurgans Sue E, Schneider Julie A, Wilson Robert S, Tran Dong, Aubin Cristin, Buchman Aron S, Heward Christopher B, Myers Amanda J, Hardy John A, Huentelman Matthew J, Corneveaux Jason J, Reiman Eric M, Evans Denis A, Bennett David A, De Jager Philip L

Abstract excerpt

OBJECTIVE: Recently, genome-wide association studies have identified 3 new susceptibility loci for Alzheimer's disease (AD), CLU, CR1, and PICALM. We leveraged available neuropsychological and autopsy data from 2 cohort studies to investigate whether these loci are associated with cognitive decline and AD neuropathology. METHODS: The Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP) are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21391232
DOI: 10.1002/ana.22277
PMCID: PMC3066288

Genes

CLU
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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