Article
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Nature genetics - 1 Oct 2009
Harold Denise, Abraham Richard, Hollingworth Paul, Sims Rebecca, Gerrish Amy, Hamshere Marian L, Pahwa Jaspreet Singh, Moskvina Valentina, Dowzell Kimberley, Williams Amy, Jones Nicola, Thomas Charlene, Stretton Alexandra, Morgan Angharad R, Lovestone Simon, Powell John, Proitsi Petroula, Lupton Michelle K, Brayne Carol, Rubinsztein David C, Gill Michael, Lawlor Brian, Lynch Aoibhinn, Morgan Kevin, Brown Kristelle S, Passmore Peter A, Craig David, McGuinness Bernadette, Todd Stephen, Holmes Clive, Mann David, Smith A David, Love Seth, Kehoe Patrick G, Hardy John, Mead Simon, Fox Nick, Rossor Martin, Collinge John, Maier Wolfgang, Jessen Frank, Schürmann Britta, Heun Reinhard, van den Bussche Hendrik, Heuser Isabella, Kornhuber Johannes, Wiltfang Jens, Dichgans Martin, Frölich Lutz, Hampel Harald, Hüll Michael, Rujescu Dan, Goate Alison M, Kauwe John S K, Cruchaga Carlos, Nowotny Petra, Morris John C, Mayo Kevin, Sleegers Kristel, Bettens Karolien, Engelborghs Sebastiaan, De Deyn Peter P, Van Broeckhoven Christine, Livingston Gill, Bass Nicholas J, Gurling Hugh, McQuillin Andrew, Gwilliam Rhian, Deloukas Panagiotis, Al-Chalabi Ammar, Shaw Christopher E, Tsolaki Magda, Singleton Andrew B, Guerreiro Rita, Mühleisen Thomas W, Nöthen Markus M, Moebus Susanne, Jöckel Karl-Heinz, Klopp Norman, Wichmann H-Erich, Carrasquillo Minerva M, Pankratz V Shane, Younkin Steven G, Holmans Peter A, O'Donovan Michael, Owen Michael J, Williams Julie
Abstract excerpt
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most signi...
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