Article
Genome-wide analysis of genetic loci associated with Alzheimer disease.
JAMA - 12 May 2010
Seshadri Sudha, Fitzpatrick Annette L, Ikram M Arfan, DeStefano Anita L, Gudnason Vilmundur, Boada Merce, Bis Joshua C, Smith Albert V, Carassquillo Minerva M, Lambert Jean Charles, Harold Denise, Schrijvers Elisabeth M C, Ramirez-Lorca Reposo, Debette Stephanie, Longstreth W T, Janssens A Cecile J W, Pankratz V Shane, Dartigues Jean François, Hollingworth Paul, Aspelund Thor, Hernandez Isabel, Beiser Alexa, Kuller Lewis H, Koudstaal Peter J, Dickson Dennis W, Tzourio Christophe, Abraham Richard, Antunez Carmen, Du Yangchun, Rotter Jerome I, Aulchenko Yurii S, Harris Tamara B, Petersen Ronald C, Berr Claudine, Owen Michael J, Lopez-Arrieta Jesus, Varadarajan Badri N, Becker James T, Rivadeneira Fernando, Nalls Michael A, Graff-Radford Neill R, Campion Dominique, Auerbach Sanford, Rice Kenneth, Hofman Albert, Jonsson Palmi V, Schmidt Helena, Lathrop Mark, Mosley Thomas H, Au Rhoda, Psaty Bruce M, Uitterlinden Andre G, Farrer Lindsay A, Lumley Thomas, Ruiz Agustin, Williams Julie, Amouyel Philippe, Younkin Steve G, Wolf Philip A, Launer Lenore J, Lopez Oscar L, van Duijn Cornelia M, Breteler Monique M B
Abstract excerpt
CONTEXT: Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD). OBJECTIVES: To identify and strengthen additional loci associated with AD and confirm these in an independent sample and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage analysis of new and previously published GWAS on more...
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