Article
CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations.
Molecular neurobiology - 1 Apr 2016
Zhang Shuyan, Li Xuling, Ma Guoda, Jiang Yongshuai, Liao Mingzhi, Feng Rennan, Zhang Liangcai, Liu Jiafeng, Wang Guangyu, Zhao Bin, Jiang Qinghua, Li Keshen, Liu Guiyou
Abstract excerpt
Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer's disease (AD) in Caucasian ancestry. Both rs11136000 and rs2279590 variants were successfully replicated in Asian population. However, previous studies reported either a weak association or no association between...