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Article

Alzheimer's disease genetics: current knowledge and future challenges.

International journal of geriatric psychiatry - 1 Aug 2011

Hollingworth Paul, Harold Denise, Jones Lesley, Owen Michael J, Williams Julie

Abstract excerpt

Alzheimer's disease (AD) is highly heritable, but genetically complex. Recently, three large-scale genome-wide association studies have made substantial breakthroughs in disentangling the genetic architecture of the disease. These studies combined include data from over 43 000 independent individuals and provide compelling evidence that variants in four novel susceptibility genes (CLU, PICALM, CR1, BIN1) are...

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Source

Identifiers

PMID: 20957767
DOI: 10.1002/gps.2628

Genes

BIN1
CLU
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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