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Number of somatic mutations in the mitochondrial D-loop region indicates poor prognosis in breast cancer, independent of TP53 mutation.

Cancer genetics and cytogenetics - 1 Sept 2010

Kuo Shou-Jen, Chen Ming, Ma Gwo-Chin, Chen Shou-Tung, Chang Shun-Ping, Lin Wen-Yin, Chen Yen-Chieh, Lee Tsung-Hsien, Lin Ta-Tsung, Liu Chin-San

Abstract excerpt

The objective of this study was to investigate whether somatic mutations in the mitochondrial DNA (mtDNA) D-loop region correlate with known prognostic factors, namely, age, tumor size, lymph node status, metastasis, tumor-node-metastasis stage, lymphovascular invasion, and status of the progesterone receptor, estrogen receptor, ERBB2 (alias HER2/neu), and TP53 proteins (as determined by immunohistochemistry) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20682393
DOI: 10.1016/j.cancergencyto.2010.05.013

Genes

ERBB2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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