Article
Mitochondrial D310 instability in Asian Indian breast cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2013
Alhomidi Mohammed A, Vedicherla Bhavani, Movva Sireesha, Rao Prabhakar K, Ahuja Yog R, Hasan Qurratulain
Abstract excerpt
Somatic mutations in mitochondrial DNA (mtDNA) have been demonstrated in various tumors. Mitochondrial D-loop is a non-coding region in the mitochondrial genome, which has essential transcription and replication elements, and alterations in this region may affect both these processes. The D-loop has a poly-C tract (PCT) located between 303 and 315 nucleotides known as D310, which has been identified as a frequent...
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