The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

doi:10.1158/1078-0432.CCR-05-1029

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2006

Olivier Magali, Langerød Anita, Carrieri Patrizia, Bergh Jonas, Klaar Sigrid, Eyfjord Jorunn, Theillet Charles, Rodriguez Carmen, Lidereau Rosette, Bièche Ivan, Varley Jennifer, Bignon Yves, Uhrhammer Nancy, Winqvist Robert, Jukkola-Vuorinen Arja, Niederacher Dieter, Kato Shunsuke, Ishioka Chikashi, Hainaut Pierre, Børresen-Dale Anne-Lise

Abstract excerpt

To investigate the clinical value of somatic TP53 mutations in breast cancer, we assembled clinical and molecular data on 1,794 women with primary breast cancer with long-term follow-up and whose tumor has been screened for mutation in exons 5 to 8 of TP53 by gene sequencing. TP53 mutations were more frequent in tumors of ductal and medullar types, aggressive phenotype (high grade, large size, node positive...

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PMID: 16489069
DOI: 10.1158/1078-0432.CCR-05-1029

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