Article
Mutations of mitochondrial DNA as potential biomarkers in breast cancer.
Anticancer research - 1 Dec 2011
Cai Feng Feng, Kohler Corina, Zhang Bei, Chen Wei Jie, Barekati Zeinab, Garritsen Henk S P, Lenner Per, Toniolo Paolo, Zhang Jing Jie, Zhong Xiao Yan
Abstract excerpt
BACKGROUND: Alterations of mitochondrial DNA (mtDNA) have been found in cancer patients, therefore informative mtDNA mutations could serve as biomarkers for the disease. MATERIALS AND METHODS: The two hypervariable regions HVR1 and HVR2 in the D-Loop region were sequenced in ten paired tissue and plasma samples from breast cancer patients. RESULTS: MtDNA mutations were found in all patients' samples, suggesting a...
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