Article
Current understanding of mitochondrial DNA in breast cancer.
The breast journal - 1 Jan 2000
Radpour Ramin, Fan Alex XiuCheng, Kohler Corina, Holzgreve Wolfgang, Zhong Xiao Yan
Abstract excerpt
The recent surge in mitochondrial research has been driven by the identification of mitochondria-associated diseases and the role of mitochondria in apoptosis and aging. Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis because of its high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. As mtDNA lacks introns, it has been suggested that most...
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