Article
Identification of sequence polymorphism in the D-loop region of mitochondrial DNA as a risk factor for breast cancer.
Cancer science - 1 Dec 2024
Nie Qian, Zhang Wenzhe, Lin Songping, Huang Meng, Li Yan, Qiu Yibin, Li Jing, Chen Xiaobin, Wang Yali, Tong Xin, Wu Jinqiao, He Peng, Cai Qindong, Chen Lili, Chen Minyan, Guo Wenhui, Lin Yuxiang, Yu Liuwen, Hou Jialin, Cai Weifeng, Chen Hanxi, Wang Chuan, Fu Fangmeng
Abstract excerpt
Mitochondrial DNA (mtDNA) variations affect the efficiency of the electron transport chain and production of reactive oxygen species, contributing to carcinogenesis. The D-loop region of mtDNA has emerged as a variation hotspot region in human neoplasia; however, the potential contribution of these variations in breast cancer risk prediction remains unknown. We investigated the relationship between germline...
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