Article
High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas.
Cancer research - 15 Aug 2001
Liu V W, Shi H H, Cheung A N, Chiu P M, Leung T W, Nagley P, Wong L C, Ngan H Y
Abstract excerpt
To investigate the potential role of somatic mitochondrial DNA (mtDNA) mutations in tumorigenesis, the occurrence of mutations in mtDNA of ovarian carcinomas was studied. We sequenced the D-loop region of mtDNA of 15 primary ovarian carcinomas and their matched normal controls. Somatic mtDNA mutations were detected in 20% (3 of 15) tumor samples carrying single or multiple changes. Complete sequence analysis of...
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