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Sequence variations of mitochondrial DNA D-loop region are highly frequent events in familial breast cancer.

Journal of biomedical science - 1 Jul 2008

Yu Man, Shi Yurong, Zhang Fei, Zhou Yunli, Yang Yi, Wei Xiyin, Zhang Lin, Niu Ruifang

Abstract excerpt

Mitochondrial DNA (mtDNA) is known for its high frequencies of polymorphisms and mutations. The non-coding displacement (D)-loop, especially a mononucleotide repeat (poly-C) between 303 and 315 nucleotides (D310), has been recently identified as a frequent hotspot of mutations in human neoplasia, including breast cancer. To further explore the sequence variations of mitochondrial D-loop region in familial breast...

Topics

Adult
Asian People
Breast Neoplasms
Case-Control Studies
DNA Mutational Analysis
DNA, Mitochondrial
Family
Female
Humans
Middle Aged
Molecular Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymorphism, Genetic

Source

Identifiers

PMID: 18157618
DOI: 10.1007/s11373-007-9229-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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