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Article

Mitochondrial D-loop mutation is a common event in colorectal cancers with p53 mutations.

International journal of colorectal disease - 1 Jun 2009

Chang Shih-Ching, Lin Pei-Ching, Yang Shung-Haur, Wang Huann-Sheng, Liang Wen-Yih, Lin Jen-Kou

Abstract excerpt

PURPOSE: p53 is the most frequently mutated gene in colorectal cancer. In mitochondria, p53 protein is involved in regulation of transcription/replication and maintenance of genomic stability. Our aim was to examine the relationship between p53, D-loop mutation, and mitochondrial DNA content in colorectal cancer (CRC). METHODS: A total of 194 patients with sporadic CRC without microsatellite instability who...

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Identifiers

PMID: 19198855
DOI: 10.1007/s00384-009-0663-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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