Article
Identification of sequence polymorphisms in the mitochondrial displacement loop as risk factors for sporadic and familial breast cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2014
Cheng Meng, Guo Zhanjun, Li Haiping, Li Zheng, Li Chunxiao, Geng Cuizhi
Abstract excerpt
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for different types of cancers, and the association of these SNPs with cancer risk and disease outcome has been exhaustively studied. We sequenced a region of approximately 1 kb flanking the majority of the D-Loop in the DNA from the blood of breast cancer patients and the...
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